Will Mayweather ever lose?

I used to not think much of Floyd Mayweather, but recently he has grown on me. He is for sure the best boxer pound-for-pound. I do like his style of a boxer shouldn't get hit. However, I do believe he didn't do enough to be de la hoya. Granted Floyd landed cleaner shot, but Oscar was pushing the fight. Anyway, after he ko'd Hatton in the 10th, can he lose? Hatton put on a good performance, but knew off the getgo, Mayweather would take him. Mayweather is a slick mother you know what. He's only 30, and he's 39-0. If he does fight again, I think the only person that has a chance is Cotto. However, Floyd's defensive is superb. Your thoughts please!